Potassium dihydrogen phosphate catalyzed one-pot synthesis of 2,4,5-triaryl-1H-imidazoles

• Published in: Chinese chemical letters Vol. 21; no. 4; pp. 429 - 432
• Main Authors: Joshi, Ratnadeep S., Mandhane, Priyanka G., Shaikh, Mohammad U., Kale, Rajesh P., Gill, Charansingh H.
• Format: Journal Article
• Language: English
• Published: Department of Chemistry,Dr.Babasaheb Ambedkar Marathwada University,Aurangabad,Maharashtra 431004,India 01.04.2010
• Subjects: Benzil; Potassium dihydrogen phosphate(KH2PO4); Ammonium acetate; 2,4,5-Triaryl-1H-imidazole; Aldehyde; Benzoin
• ISSN: 1001-8417; 1878-5964
• DOI: 10.1016/j.cclet.2009.11.012

A simple and efficient method has been developed;benzil/benzoin undergoes smooth condensation with various substituted aldehyde and ammonium acetate in the presence of potassium dihydrogen phosphate(KH_2PO_4) under mild reaction conditions to afford the corresponding trisubstituted imidazole in excellent yields.The method for synthesis of product,the reaction mixture was reflux in ethanol for 40-90 min.The present method is simple,efficient,and cost-effective.