T Cell Receptor Cross-Reactivity between Similar Foreign and Self Peptides Influences Naive Cell Population Size and Autoimmunity

• Published in: Immunity (Cambridge, Mass.) Vol. 42; no. 6; pp. 1212 - 1213
• Main Authors: Nelson, Ryan W., Beisang, Daniel, Tubo, Noah J., Dileepan, Thamotharampillai, Wiesner, Darin L., Nielsen, Kirsten, Wüthrich, Marcel, Klein, Bruce S., Kotov, Dmitri I., Spanier, Justin A., Fife, Brian T., Moon, James J., Jenkins, Marc K.
• Format: Journal Article
• Language: English
• Published: Cambridge Elsevier Inc 16.06.2015; Elsevier Limited
• Subjects: Peptides; T cell receptors
• ISSN: 1074-7613; 1097-4180
• DOI: 10.1016/j.immuni.2015.06.007

[...]neither the level of statistical significance of the correlation between the number of self peptide homologs and the number of naive cells specific for foreign peptides shown in Figure 4G nor the conclusion that "TCR cross-reactivity on self-peptide homologs plays some role in determining the size of MHCII-bound foreign peptide-specific CD4+ T cell populations" were changed. [...]none of these errors affect any of the conclusions of the paper.