Synthesis, characterization and biological activity of a novel binuclear organotin complex, Ph3Sn(HL)·Ph2SnL [L = 3,5-Br2-2-OC6H2CHNCH(i-Pr)COO]

• Published in: Applied organometallic chemistry Vol. 19; no. 10; pp. 1127 - 1131
• Main Authors: Tian, Laijin, Sun, Yuxi, Qian, Bochu, Yang, Guoming, Yu, You, Shang, Zhicai, Zheng, Xiaoliang
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.10.2005; Wiley
• Subjects: Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antineoplastic agents; binuclear tin complex; Biological and medical sciences; Chemistry; cytotoxic activity; Exact sciences and technology; Ge, sn, pb derivatives; General aspects; Medical sciences; Organic chemistry; Organometalloidal and organometallic compounds; organotin carboxylate; Pharmacology. Drug treatments; Preparations and properties; X-ray structure; Antineoplastic agent; Phenolate; organotin carboxylate; Molecular structure; Escherichia coli; Aryloxy complex; Cytotoxicity; Uterine cervix; Bacteria; Micrococcales; Micrococcaceae; Colon; Mammary gland; cytotoxic activity; Chemical synthesis; Tumor cell; Staphylococcus aureus; Enterobacteriaceae; Human; binuclear tin complex; Organic ligand; X ray diffraction; In vitro; Hela cell line; Biological activity; α-Aminoacid; Cell line; Carboxylate; Dinuclear complex; Tin Organic compounds; Antibacterial agent; X-ray structure; Crystalline structure
• ISSN: 0268-2605; 1099-0739
• DOI: 10.1002/aoc.968

A 1:1 reaction of triphenyltin chloride with potassium N‐[(3,5‐dibromo‐2‐hydroxyphenyl)methylene] valinate in benzene under reflux leads to the formation of a novel mixed organotin binuclear complex, Ph3Sn(HL)·Ph2SnL [L = 3,5‐Br2‐2‐OC6H2CHNCH(i‐Pr)COO], by means of a facile phenyl–tin bond cleavage process. The X‐ray structure reveals that there are two distinct types of carboxylate coordination mode and trans‐O2SnC2N and trans‐O2SnC3 in distorted trigonal bipyramidal geometries. The complex displays good in vitro cytotoxicity and antibacterial activities. Copyright © 2005 John Wiley & Sons, Ltd. The 1:1 reaction of triphenyltin chloride with potassium N‐[(3,5‐dibromo‐2‐hydroxyphenyl)methylene]valinate leads to the formation of the title compound by means of a facile SnC bond cleavage process. The complex contains trans‐O2SnC2N and trans‐O2SnC3 distorted trigonal bipyramidal geometries linked by a bridging carboxylate group. The compound exhibits good cytotoxicity and antibacterial activity.