Ganglionated Plexi Modulate Extrinsic Cardiac Autonomic Nerve Input

• Published in: Journal of the American College of Cardiology Vol. 50; no. 1; pp. 61 - 68
• Main Authors: Hou, Yinglong, MD, Scherlag, Benjamin J., PhD, Lin, Jiaxiong, MD, Zhang, Ying, MD, PhD, Lu, Zhibing, MD, Truong, Kim, DO, Patterson, Eugene, PhD, Lazzara, Ralph, MD, Jackman, Warren M., MD, Po, Sunny S., MD, PhD
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.07.2007
• Subjects: Cardiovascular; Internal Medicine; effective refractory period; RSPV; ERP; right superior pulmonary vein; autonomic nervous system; ARGP; SLGP; AF; ANS; GP; ganglionated plexi; ventricular rate; inferior right ganglionated plexi; anterior right ganglionated plexi; LSPV; left superior pulmonary vein; SA; sinoatrial; IRGP; atrial fibrillation; sinus rate; superior left ganglionated plexi; VR; SR
• ISSN: 0735-1097; 1558-3597
• DOI: 10.1016/j.jacc.2007.02.066

Ganglionated Plexi Modulate Extrinsic Cardiac Autonomic Nerve Input: Effects on Sinus Rate, Atrioventricular Conduction, Refractoriness, and Inducibility of Atrial Fibrillation Yinglong Hou, Benjamin J. Scherlag, Jiaxiong Lin, Ying Zhang, Zhibing Lu, Kim Truong, Eugene Patterson, Ralph Lazzara, Warren M. Jackman, Sunny S. Po Sinus rate and ventricular rate during atrial fibrillation were assessed before and after left or right vagosympathetic trunk stimulation. The same parameters were assessed after sequential ablation of superior left ganglionated plexi (SLGP), anterior right ganglionated plexi (ARGP), and inferior right ganglionated plexi. Changes in effective refractory period and atrial fibrillation inducibility with unilateral right and left vagosympathetic trunk stimulation were assessed after ablation of ARGP and SLGP, respectively. We found that ganglionated plexi function as the “integration centers” to modulate the autonomic interaction between extrinsic and intrinsic cardiac autonomic nervous system.