Diagnostic Accuracy of Coronary In-Stent Restenosis Using 64-Slice Computed Tomography

• Published in: Journal of the American College of Cardiology Vol. 49; no. 9; pp. 951 - 959
• Main Authors: Ehara, Mariko, MD, Kawai, Masato, RT, Surmely, Jean-François, MD, Matsubara, Tetsuo, MD, Terashima, Mitsuyasu, MD, Tsuchikane, Etsuo, MD, Kinoshita, Yoshihisa, MD, Ito, Tatsuya, MD, Takeda, Yoshihiro, MD, Nasu, Kenya, MD, Tanaka, Nobuyoshi, MD, Murata, Akira, MD, Fujita, Hiroshi, MD, Sato, Koyo, MD, Kodama, Atsuko, MD, Katoh, Osamu, MD, Suzuki, Takahiko, MD
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.03.2007
• Subjects: Cardiovascular; Internal Medicine; computed tomography; positive predictive value; in-stent restenosis; CI; computed tomography coronary angiography; ICA; invasive coronary angiography; ISR; DS; CTCA; CT; percent diameter stenosis; MSCT; NPV; PPV; confidence interval; multislice computed tomography; negative predictive value
• ISSN: 0735-1097; 1558-3597
• DOI: 10.1016/j.jacc.2006.10.065

Diagnostic Accuracy of Coronary In-Stent Restenosis Using 64-Slice Computed Tomography: Comparison With Invasive Coronary Angiography Mariko Ehara, Masato Kawai, Jean-François Surmely, Tetsuo Matsubara, Mitsuyasu Terashima, Etsuo Tsuchikane, Yoshihisa Kinoshita, Tatsuya Ito, Yoshihiro Takeda, Kenya Nasu, Nobuyoshi Tanaka, Akira Murata, Hiroshi Fujita, Koyo Sato, Atsuko Kodama, Osamu Katoh, Takahiko Suzuki To evaluate the diagnostic accuracy of coronary in-stent restenosis with 64-slice multislice computed tomography coronary angiography (CTCA), we scanned 125 stented segments and compared with invasive coronary angiography (ICA). Overall sensitivity, specificity, positive predictive values, and negative predictive values by CTCA were 92%, 81%, 54%, and 98%, respectively. Grading of neointimal proliferation with visual estimation by CTCA showed a correlation with the percent diameter stenosis by ICA, and as the grade increases, the median value of percent diameter stenosis increased linearly. Our results show that binary restenosis can be excluded with high probability by CTCA, with a moderate rate of false-positive results.