A Meta-Analysis of the Effect of Exercise Training on Left Ventricular Remodeling in Heart Failure Patients

• Published in: Journal of the American College of Cardiology Vol. 49; no. 24; pp. 2329 - 2336
• Main Authors: Haykowsky, Mark J., PhD, Liang, Yuanyuan, PhD, Pechter, David, BA, Jones, Lee W., PhD, McAlister, Finlay A., MD, MSc, Clark, Alexander M., PhD
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.06.2007
• Subjects: Cardiovascular; Internal Medicine; EF; heart failure; ejection fraction; CI; weighted mean difference; ESV; end-systolic volume; LV; SMD; standardized mean difference; WMD; V o 2peak; EDV; peak oxygen consumption; confidence interval; end-diastolic volume; left ventricle/ventricular; HF; Vo2peak
• ISSN: 0735-1097; 1558-3597
• DOI: 10.1016/j.jacc.2007.02.055

A Meta-Analysis of the Effect of Exercise Training on Left Ventricular Remodeling in Heart Failure Patients: The Benefit Depends on the Type of Training Performed Mark J. Haykowsky, Yuanyuan Liang, David Pechter, Lee W. Jones, Finlay A. McAlister, Alexander M. Clark The aim of our meta-analysis was to determine the effect of exercise training and type of exercise (aerobic, strength, or combined training) on ventricular remodeling in individuals with clinically stable heart failure. We found that aerobic training was associated with a significant increase in ejection fraction and a concomitant decline in ventricular volumes. Conversely, combined aerobic and strength training did not alter ventricular volumes or ejection fraction. Accordingly, aerobic training is an effective therapy to reverse ventricular remodeling in clinically stable individuals with heart failure. However, this benefit does not occur with combined aerobic and strength training.