Growth of an endometrial polyp in a postmenopausal patient using raloxifene

Objective To describe the association of raloxifene use with the development of an endometrial polyp in a postmenopausal patient. Design Case report study. Results Hysterosonography and hysteroscopy showed the occurrence of an endometrial polyp in a postmenopausal patient who had been using raloxife...

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Bibliographic Details
Published inGynaecological endoscopy Vol. 9; no. 2; pp. 117 - 121
Main Authors Maia Jr, Hugo, Maltez, Amelia, Oliveira, Maita, Almeida, Marta, Coutinho, Elsimar M.
Format Journal Article
LanguageEnglish
Published Oxford, U.K. and Cambridge, USA Blackwell Science Ltd 01.04.2000
Subjects
endometrial polyp
p53
polypectomy
raloxifene
tamoxifen
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Summary:Objective To describe the association of raloxifene use with the development of an endometrial polyp in a postmenopausal patient. Design Case report study. Results Hysterosonography and hysteroscopy showed the occurrence of an endometrial polyp in a postmenopausal patient who had been using raloxifene for 8 months. Pathological investigation showed the presence of simple hyperplasia in the polyp. Oestrogen receptors were present in both the polyp and the atrophic endometrium. Progesterone receptors, on the other hand, were detected mainly in the atrophic endometrium. There was a focal p53 overexpression in the glandular epithelium of the polyp. Conclusion Raloxifene stimulated the development of an endometrial polyp in this postmenopausal patient. The presence of progesterone receptors in the atrophic endometrium suggests an agonistic action of raloxifene on this tissue.
ISSN:0962-1091
1365-2508
DOI:10.1046/j.1365-2508.2000.00304.x