Growth of an endometrial polyp in a postmenopausal patient using raloxifene
Objective To describe the association of raloxifene use with the development of an endometrial polyp in a postmenopausal patient. Design Case report study. Results Hysterosonography and hysteroscopy showed the occurrence of an endometrial polyp in a postmenopausal patient who had been using raloxife...
Saved in:
Published in | Gynaecological endoscopy Vol. 9; no. 2; pp. 117 - 121 |
---|---|
Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Oxford, U.K. and Cambridge, USA
Blackwell Science Ltd
01.04.2000
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | Objective
To describe the association of raloxifene use with the development of an endometrial polyp in a postmenopausal patient.
Design
Case report study.
Results
Hysterosonography and hysteroscopy showed the occurrence of an endometrial polyp in a postmenopausal patient who had been using raloxifene for 8 months. Pathological investigation showed the presence of simple hyperplasia in the polyp. Oestrogen receptors were present in both the polyp and the atrophic endometrium. Progesterone receptors, on the other hand, were detected mainly in the atrophic endometrium. There was a focal p53 overexpression in the glandular epithelium of the polyp.
Conclusion
Raloxifene stimulated the development of an endometrial polyp in this postmenopausal patient. The presence of progesterone receptors in the atrophic endometrium suggests an agonistic action of raloxifene on this tissue. |
---|---|
ISSN: | 0962-1091 1365-2508 |
DOI: | 10.1046/j.1365-2508.2000.00304.x |