Statin Effects on Vascular Calcification: Microarchitectural Changes in Aortic Calcium Deposits in Aged Hyperlipidemic Mice

• Published in: Arteriosclerosis, thrombosis, and vascular biology Vol. 41; no. 4; pp. e185 - e192
• Main Authors: Xian, Joshua Zhaojun, Lu, Mimi, Fong, Felicia, Qiao, Rong, Patel, Nikhil Rajesh, Abeydeera, Dishan, Iriana, Sidney, Demer, Linda L, Tintut, Yin
• Format: Journal Article
• Language: English
• Published: United States 01.04.2021
• Subjects: Age Factors; Animals; Aorta - diagnostic imaging; Aorta - drug effects; Aorta - metabolism; Aorta - pathology; Aortic Diseases - diagnostic imaging; Aortic Diseases - drug therapy; Aortic Diseases - metabolism; Aortic Diseases - pathology; Atherosclerosis - diagnostic imaging; Atherosclerosis - drug therapy; Atherosclerosis - metabolism; Atherosclerosis - pathology; Calcium - metabolism; Disease Models, Animal; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology; Hyperlipidemias - blood; Hyperlipidemias - drug therapy; Lipids - blood; Mice; Mice, Inbred C57BL; Mice, Knockout, ApoE; Plaque, Atherosclerotic; Pravastatin - pharmacology; Rupture, Spontaneous; Time Factors; Vascular Calcification - diagnostic imaging; Vascular Calcification - drug therapy; Vascular Calcification - metabolism; Vascular Calcification - pathology; atherosclerosis; pravastatin; vascular calcification; aging; artery; positron emission tomography; vascular

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