Influence of high dietary threonine on growth and amino acids in blood and tissues of rats

Diets containing 8 or 15% protein from casein plus limiting amino acids, 25% fat and adequate levels of other nutrients for rat growth were supplemented with 0, 0.5, 1.0, 2.0 or 4% of excess L-threonine. Addition of up to 1% excess threonine had little effect on weight gains or food intakes of weanl...

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Bibliographic Details
Published inAmino acids Vol. 8; no. 1; pp. 69 - 78
Main Authors Sarwar, G, Peace, R.W, Botting, H.G
Format Journal Article
LanguageEnglish
Published Austria 01.03.1995
Subjects
casein
nutrient excess
threonine
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Summary:Diets containing 8 or 15% protein from casein plus limiting amino acids, 25% fat and adequate levels of other nutrients for rat growth were supplemented with 0, 0.5, 1.0, 2.0 or 4% of excess L-threonine. Addition of up to 1% excess threonine had little effect on weight gains or food intakes of weanling rats, but addition of 2 and 4% threonine caused a drastic reduction in weight gains or food intakes (up to 41%); the adverse effect being more severe in rats fed lower protein diets. Addition of graded levels of excess threonine resulted in (5 to 47-fold and 4 to 20-fold) increase in concentration of free threonine in rat plasma and brain, respectively. Addition of excess threonine also caused up to 5-fold increase in plasma level of 3-methylhistidine, suggesting increased muscle protein breakdown.
Bibliography:ObjectType-Article-1
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ISSN:0939-4451
1438-2199
DOI:10.1007/BF00806545