Biofilm and bacterial membrane vesicles: recent advances

Bacterial Membrane Vesicles (MVs) play important roles in cell-to-cell communication and transport of several molecules. Such structures are essential components of Extracellular Polymeric Substances (EPS) biofilm matrix of many bacterial species displaying a structural function and a role in virule...

Full description

Saved in:
Bibliographic Details
Published inExpert opinion on therapeutic patents Vol. 34; no. 6; p. 475
Main Authors Puca, Valentina, Marinacci, Beatrice, Pellegrini, Benedetta, Campanile, Floriana, Santagati, Maria, Grande, Rossella
Format Journal Article
LanguageEnglish
Published England 02.06.2024
Subjects
Animals
Anti-Bacterial Agents - pharmacology
Bacteria
Bacterial Infections - drug therapy
Bacterial Infections - microbiology
Biofilms - drug effects
Drug Development
Extracellular Vesicles - metabolism
Humans
Patents as Topic
Virulence
Biofilm
biofilm formation
extracellular vesicles
outer membrane vesicles
membrane vesicles
Online AccessGet more information

Cover

More Information
Summary:Bacterial Membrane Vesicles (MVs) play important roles in cell-to-cell communication and transport of several molecules. Such structures are essential components of Extracellular Polymeric Substances (EPS) biofilm matrix of many bacterial species displaying a structural function and a role in virulence and pathogenesis. In this review were included original articles from the last ten years by searching the keywords 'biofilm' and 'vesicles' on PUBMED and Scopus databases. The articles available in literature mainly describe a positive correlation between bacterial MVs and biofilms formation. The research on Espacenet and Google Patent databases underlines the available patents related to the application of both biofilm MVs and planktonic MVs in inhibiting biofilm formation. This review covers and analyzes recent advances in the study of the relationship between bacterial vesicles and biofilm. The huge number of papers discussing the role of MVs confirms the interest aimed at developing new applications in the medical field. The study of the MVs composition and biogenesis may contribute to the identification of components which could be (i) the target for the development of new drugs inhibiting the biofilm establishment; (ii) candidates for the development of vaccines; (iii) biomarkers for the diagnosis of bacterial infections.
ISSN:1744-7674
DOI:10.1080/13543776.2024.2338101