Differences in binding of nuclear proteins from P. berghei strains differing by chloroquine resistance to oligonucleotides corresponding to mdr1 gene regulatory elements

Proteins specifically reacting with AP1, MEF1, NF-IL6, and SP1 transcription factor binding sites were detected for the first time in nuclear extract of P. berghei (rodent malaria parasite) using gel retardation assay. P. berghei strains with different chloroquine resistance exhibited appreciable di...

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Bibliographic Details
Published inBulletin of experimental biology and medicine Vol. 141; no. 3; pp. 312 - 314
Main Authors Pankova, T G, Igonina, T M, Kobzev, V F, Merkulova, T I
Format Journal Article
LanguageEnglish
Published United States Springer Nature B.V 01.03.2006
Subjects
Animals
Antimalarials - pharmacology
ATP-Binding Cassette Transporters - genetics
Base Sequence
Chloroquine - pharmacology
DNA Primers
Drug Resistance - genetics
Nuclear Proteins - metabolism
Plasmodium berghei - drug effects
Plasmodium berghei - genetics
Plasmodium berghei - metabolism
Protein Binding
Protozoan Proteins - genetics
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Summary:Proteins specifically reacting with AP1, MEF1, NF-IL6, and SP1 transcription factor binding sites were detected for the first time in nuclear extract of P. berghei (rodent malaria parasite) using gel retardation assay. P. berghei strains with different chloroquine resistance exhibited appreciable differences in the pattern of nuclear protein binding to the majority of the studied sites, which attests to changes in the plasmodial regulatory system during chloroquine resistance selection.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-006-0158-4