Tear trough rejuvenation: A safety evaluation of the treatment by a semi-cross-linked hyaluronic acid filler

• Published in: Orbit (Amsterdam) Vol. 36; no. 1; pp. 22 - 26
• Main Authors: Berguiga, Marouen, Galatoire, Olivier
• Format: Journal Article
• Language: English
• Published: England 01.02.2017
• Subjects: Cosmetic Techniques; Dermal Fillers - administration & dosage; Dermal Fillers - adverse effects; Female; Humans; Hyaluronic Acid - administration & dosage; Hyaluronic Acid - adverse effects; Injections, Subcutaneous; Lacrimal Apparatus - drug effects; Male; Mesotherapy; Middle Aged; Patient Satisfaction - statistics & numerical data; Prospective Studies; Rejuvenation; Skin Aging - drug effects; Viscosupplements - administration & dosage; Viscosupplements - adverse effects; tear trough; hollow ring; Cosmetic medicine; hyaluronic acid fillers; non-invasive facial rejuvenation
• ISSN: 0167-6830; 1744-5108
• DOI: 10.1080/01676830.2017.1279641

The aim of this study is to describe the experience of 33 physicians, dermatologists and surgeons, with the use of a semi-cross-linked hyaluronic acid (HA) gel as a tear trough deformity filler within one month following injection, and to assess patient satisfaction with the procedure. This study is a case series conducted between February 2012 and December 2012 with the use of semi-cross-linked HA to correct tear trough deformity. The filler was administered in the preperiosteal tissues. The study involved case note review and a patient satisfaction survey. A total of 302 eyes of 151 patients were treated by 33 physicians, with a mean follow-up of 3 weeks. Patients were mainly female (86%), and middle-aged (mean age 48 years old). The gel was placed preperiosteally, deep to the orbicularis, anterior to the inferior orbital rim, with a mean volume of 0.48 ml per eye to achieve correction. The injection procedure was performed without local anesthetic for 79% of the patients. No serious adverse event was recorded. Side effects reported by investigators immediately after injection included bruising (11%), swelling (12%), and redness (inflammation 12%). Very few transitional blue discolorations (2.6%) were observed. No patient required dissolution with hyaluronidase. According to our satisfaction survey, all patients had cosmetic improvement. Most patients (97%) described marked or moderate satisfaction with the treatment. At one month, 18% requested additional hyaluronic acid gel for a touch-up injection. This case series confirms the effective use of a semi-cross-linked HA gel in tear trough rejuvenation. It has excellent patient tolerability, minimal complications, and excellent patient satisfaction.