Various Formulations of Glycyrrhizic Acid and the Possibility of Their Use in Virus-Associated and Inflammatory Diseases

Pharmaceuticals containing glycyrrhizic acid that exhibit a pleiotropic effect and reduce the risk of progression of cervical lesions associated with human papillomavirus, virus-associated liver lesions, and other diseases with an inflammatory component are considered. Glycyrrhizic acid obtained fro...

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Bibliographic Details
Published inPharmaceutical chemistry journal Vol. 57; no. 4; pp. 467 - 475
Main Authors Filimonova, M. S., Shimanovsky, N. L.
Format Journal Article
LanguageEnglish
Published New York Springer US 01.07.2023
Springer
Subjects
Amino acids
Cervical cancer
Development and progression
Health aspects
Immunotherapy
Medicine
Molecular-Biological Problems of Drug Design and Mechanism of Drug Action
Organic Chemistry
Papillomavirus infections
Pharmacology/Toxicology
Pharmacy
Squamous intraepithelial cervical lesion
glycyrrhizic acid
antiproliferation action
antiviral action
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Summary:Pharmaceuticals containing glycyrrhizic acid that exhibit a pleiotropic effect and reduce the risk of progression of cervical lesions associated with human papillomavirus, virus-associated liver lesions, and other diseases with an inflammatory component are considered. Glycyrrhizic acid obtained from licorice root extract has immunostimulatory, anti-inflammatory, antiproliferative, and pro-apoptotic effects. The mechanisms of action of glycyrrhizic acid at the cellular level that provide the therapeutic efficacy are considered.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-023-02907-z