Portal vein thrombosis as the presenting manifestation of JAK2 positive myeloproliferative neoplasm

Deep venous thrombosis (DVT) is a complication of myeloproliferative neoplasms (MPNs). However, DVTs in unusual sites such as portal vein thrombosis (PVT) are rare and may be the first clinical manifestation of occult MPNs. There is a need for increasing awareness of such manifestations; so, here we...

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Bibliographic Details
Published inThe American journal of the medical sciences Vol. 365; no. 5; p. 457
Main Authors Jeon, Won Jin, Mehta, Akhil, Hudson, Jessica, Castillo, Dani Ran, Wang, Jun, Nguyen, Anthony, Akhtari, Mojtaba
Format Journal Article
LanguageEnglish
Published United States 01.05.2023
Subjects
Bone Marrow Neoplasms
Humans
Janus Kinase 2 - genetics
Liver Diseases
Mutation
Myeloproliferative Disorders - complications
Myeloproliferative Disorders - diagnosis
Portal Vein - diagnostic imaging
Thrombosis - etiology
Venous Thrombosis - diagnostic imaging
Venous Thrombosis - drug therapy
Venous Thrombosis - etiology
Deep vein thrombosis
Polycythemia vera
JAK2
Myeloproliferative neoplasms
Philadelphia chromosome
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Summary:Deep venous thrombosis (DVT) is a complication of myeloproliferative neoplasms (MPNs). However, DVTs in unusual sites such as portal vein thrombosis (PVT) are rare and may be the first clinical manifestation of occult MPNs. There is a need for increasing awareness of such manifestations; so, here we discuss a patient who presented with new portal vein thrombosis, underwent further studies, was ultimately diagnosed with JAK2 positive MPN, and started on appropriate treatment with improvement of thrombosis and controlled hematocrit.
ISSN:1538-2990
DOI:10.1016/j.amjms.2023.01.002