Random start controlled ovarian hyperstimulation for fertility preservation during incidental pregnancy: a case report of blastocyst vitrification from in vitro matured oocytes

Here, we present a diffuse large B cell lymphoma patient admitted for fertility preservation before cancer therapy and whose pregnancy was recognized incidentally just after the start of random start controlled ovarian stimulation (RSCOH) during the stimulation cycle. Despite an optimal homogenous g...

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Published inGynecological endocrinology Vol. 35; no. 7; pp. 564 - 566
Main Authors Şükür, Yavuz Emre, Özkavukçu, Sinan, İlhan, Fatma Ceylan, Şimşir, Coşkun, Sönmezer, Murat
Format Journal Article
LanguageEnglish
Published England 03.07.2019
Subjects
Adult
Blastocyst
Cryopreservation
Female
Fertility Preservation
Humans
In Vitro Oocyte Maturation Techniques
Lymphoma, Large B-Cell, Diffuse
Oocyte Retrieval
Ovulation Induction
Pregnancy
Vitrification
Pregnancy
random start controlled ovarian hyperstimulation
progesterone
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Summary:Here, we present a diffuse large B cell lymphoma patient admitted for fertility preservation before cancer therapy and whose pregnancy was recognized incidentally just after the start of random start controlled ovarian stimulation (RSCOH) during the stimulation cycle. Despite an optimal homogenous growth of follicle cohort, majority of the retrieved oocytes were immature after GnRHa trigger. Possible effects of extremely high serum progesterone and/or β-hCG levels on oocyte maturation are discussed with the surprising high rate of maturation and subsequent good embryo development. It seems that in case of need for pregnancy termination as a result of an urgent cancer therapy, RSCOH can be started and patients may benefit from overnight maturation of oocytes.
Bibliography:ObjectType-Case Study-2
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ISSN:0951-3590
1473-0766
DOI:10.1080/09513590.2019.1576608