Use of compounded adrenocorticotropic hormone (ACTH) for adrenal function testing in dogs

• Published in: The Journal of the American Animal Hospital Association Vol. 41; no. 6; p. 368
• Main Authors: Kemppainen, Robert J, Behrend, Ellen N, Busch, Katherine A
• Format: Journal Article
• Language: English
• Published: United States 01.11.2005
• Subjects: Adrenal Cortex Function Tests - methods; Adrenal Cortex Function Tests - veterinary; Adrenal Gland Diseases - diagnosis; Adrenal Gland Diseases - veterinary; Adrenal Glands - drug effects; Adrenal Glands - physiology; Adrenocorticotropic Hormone - pharmacokinetics; Animals; Area Under Curve; Cross-Over Studies; Dog Diseases - diagnosis; Dogs; Female; Hydrocortisone - blood; Male; Random Allocation
• ISSN: 1547-3317
• DOI: 10.5326/0410368

Serum cortisol concentrations were measured in five healthy dogs in response to five adrenocorticotropic hormone (ACTH) preparations. Cortisol concentrations were similar at time 0 (pre-ACTH) and at 30 and 60 minutes after injection of all forms of ACTH. However, at 90 and 120 minutes post-ACTH, serum cortisol concentrations were significantly lower following injection of two compounded forms of ACTH. The data showed that injection of four compounded forms of ACTH caused elevations in serum cortisol concentrations of a similar magnitude as cosyntropin in samples collected 60 minutes after administration; but concentrations at later times varied, depending on the type of ACTH used.