Postpartum intracranial hypotension complicated by posterior reversible encephalopathy syndrome: a case report

• Published in: International journal of neuroscience Vol. 130; no. 11; pp. 1 - 1177
• Main Authors: Chondrogiorgi, Maria, Zikou, Anastasia K, Konitsiotis, Spiridon, Markoula, Sofia
• Format: Journal Article
• Language: English
• Published: England 01.11.2020
• Subjects: Headache; posterior reversible encephalopathy syndrome; intracranial hypotension
• ISSN: 0020-7454; 1563-5279; 1543-5245
• DOI: 10.1080/00207454.2020.1730365

To present an unusual case of posterior encephalopathy syndrome (PRES) preceded by intracranial hypotension. We present a case of a 27-year-old parturient with an uneventful pregnancy that shortly after labor developed a persistent headache with characteristics compatible with intracranial hypotension. The patient had undergone epidural anesthesia for caesarian section.  The symptomatology of intracranial hypotension was attributed to inadvertent dural puncture during epidural anesthesia. The MRI revealed multiple white matter lesions located in frontal, temporal and parietal regions of both hemispheres. The type of lesions was suggestive of PRES. Pachymeningeal enhancement was also observed. The patient was managed conservatively. The symptoms improved gradually and the imaging findings resolved completely.  This case demonstrates the need for clinical alertness for PRES in patients with prolonged and possibly atypical symptoms of intracranial hypotension. As probable causal relationship between these disorders we propose a sympathetic over-activation as a result of cerebrospinal fluid leakage leading to vasospasm and manifestation of PRES.