Synthesis of chitosan–polycaprolactone blend for control delivery of ofloxacin drug

In the present research work chitosan has been blended with different amounts of polycaprolactone (PCL) (80:20, 75:25, 60:40 and 50:50) for using them for control delivery of ofloxacin. The blends were characterized by Fourier transmission infra red spectroscopy (FTIR), UV–visible spectroscopy (UV),...

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Bibliographic Details
Published inCarbohydrate polymers Vol. 79; no. 1; pp. 106 - 113
Main Authors Sahoo, Sarmila, Sasmal, Abhisek, Nanda, Rajashree, Phani, A.R., Nayak, P.L.
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 05.01.2010
Subjects
Blending
Chitosan
Drug delivery
Kinetics
Ofloxacin
Polycaprolactone
Drug delivery
Chitosan
Kinetics
Blending
Ofloxacin
Polycaprolactone
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Summary:In the present research work chitosan has been blended with different amounts of polycaprolactone (PCL) (80:20, 75:25, 60:40 and 50:50) for using them for control delivery of ofloxacin. The blends were characterized by Fourier transmission infra red spectroscopy (FTIR), UV–visible spectroscopy (UV), scanning electron microscopy (SEM), X-ray diffraction (XRD) analysis. From the FTIR spectra the various groups present in chitosan and PCL blend were monitored. The homogeneity, morphology and crystallinity of the blends were ascertained from SEM and XRD data, respectively. The swelling studies have been measured at different drug loading. The kinetics of the drug delivery system has been systematically studied. Drug release kinetics was analyzed by plotting the cumulative release data vs. time by fitting to an exponential equation which indicated the non-Fickian type of kinetics. The drug release was investigated at different pH medium and it was found that the drug release depends upon the pH medium as well as the nature of matrix.
ISSN:0144-8617
1879-1344
DOI:10.1016/j.carbpol.2009.07.042