Mitochondrial malate dehydrogenase (Mor-1) in the mouse: linkage to chromosome 5 markers

Malate dehydrogenase is present in most mammalian tissues in both supernatant and mitochondrial forms. Although genetic variation for the supernatant form has not been observed in the mouse, electrophoretic variants caused by alleles at the mitochondrial locus (Mor-1) have been previously described....

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Bibliographic Details
Published inBiochemical genetics Vol. 13; no. 9-10; p. 519
Main Authors Womack, J E, Hawes, N L, Soares, E R, Roderick, T H
Format Journal Article
LanguageEnglish
Published United States 01.10.1975
Subjects
Alleles
Animals
Chromosome Mapping
Crosses, Genetic
Female
Genetic Linkage
Genotype
Glucuronidase - analysis
Kidney - enzymology
Malate Dehydrogenase - analysis
Male
Mice
Mice, Inbred C57BL
Mice, Inbred CBA
Mitochondria - enzymology
Recombination, Genetic
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Summary:Malate dehydrogenase is present in most mammalian tissues in both supernatant and mitochondrial forms. Although genetic variation for the supernatant form has not been observed in the mouse, electrophoretic variants caused by alleles at the mitochondrial locus (Mor-1) have been previously described. We have located this locus 11.0 +/- 2.9 cM from the beta-glucuronidase structural gene, Gus, on chromosome 5. The gene order is Hm-Pgm-1-rd-bf-Gus-Mor-1. Thus Mor-1 is presently the most distal marker on chromosome 5. Three different nuclear loci for mitochondrial enzymes (Mod-2, Got-2, and Mor-1) have now been mapped in the mouse, all on different chromosomes.
ISSN:0006-2928
DOI:10.1007/BF00484911