A new triterpenoid from the stems of Kadsura coccinea with antiproliferative activity

• Published in: Natural product research Vol. 36; no. 10; pp. 2542 - 2546
• Main Authors: Tram, Le Huyen, Thu Huong, Tran, Thi Thuy, Le, Van Thong, Nguyen, Tuan Anh, Nguyen, Hoang Minh, Nguyen, Thu Ha, Tran, Anh Dung, Dao, Thao, Nguyen Phuong, Thuong, Phuong Thien, Le, Duc Dat, Hiep, Nguyen Dinh, Shin, Hee Jae
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 01.05.2022; Taylor & Francis Ltd
• Subjects: antiproliferative activity; Breast; Cell Line; Colon; Colon cancer; Cytotoxicity; human cancer cells; Humans; Kadsura; Kadsura coccinea; Magnetic Resonance Spectroscopy; Molecular Structure; NMR; Nuclear magnetic resonance; Plant Stems; Prostate; Schisandraceae; Stems; Toxicity; triterpene; Triterpenes - chemistry; Triterpenes - pharmacology; Triterpenoids; Tumor cell lines; triterpene; human cancer cells; Kadsura coccinea; Schisandraceae; antiproliferative activity
• ISSN: 1478-6419; 1478-6427
• DOI: 10.1080/14786419.2021.1914612

A series of schiartane C 29 nortriterpenoids with 5/5/7/6/5 membered consecutive rings (1‒5) with an unique schinortriterpenoid skeleton including a new, kadcoccilactone V (1), together with four known ones (2‒5) and three known triterpenoids (6‒8) were identified from stems of Kadsura coccinea (Lem.) A. C. Smith. The structures of 1 and known compounds were elucidated by interpretation of 1D and 2D NMR, and HR-ESI-MS data as well as comparing those data in the literature. All the isolated compounds were examined for cytotoxic effects against six human cancer cell lines [(HCT-15 (colon), NUGC-3 (stomach), NCI-H23 (lung), ACHN (renal), PC-3 (prostate), and MDA-MB-231 (breast)]. Among them, compound 6 showed potent cytotoxicity against NCI-H23 (GI 50 1.28 µM) and NUGC-3 (GI 50 1.28 µM), and significantly inhibited on PC-3, MDA-MB-231, ACHN, HCT-15 with GI 50 values around 2.33 to 2.67 µM.