Plasma Semicarbazide-Sensitive Amine Oxidase Activity is Elevated in Diabetes Mellitus and Correlates with Glycosylated Haemoglobin

• Published in: Clinical science (1979) Vol. 88; no. 6; pp. 675 - 679
• Main Authors: Boomsma, Frans, Derkx, Frans H. M., van den Meiracker, Anton H., man in't Veld, Arie J., Schalekamp, Maarten A. D. H.
• Format: Journal Article
• Language: English
• Published: London Portland Press 01.06.1995
• Subjects: Adult; Albuminuria - metabolism; Amine Oxidase (Copper-Containing) - blood; Biological and medical sciences; Diabetes Mellitus, Type 1 - enzymology; Diabetes. Impaired glucose tolerance; Diabetic Nephropathies - enzymology; Diabetic Retinopathy - enzymology; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Female; Glycated Hemoglobin A - metabolism; Humans; Male; Medical sciences; Middle Aged; Endocrinopathy; Human; Enzymatic activity; Pathophysiology; Insulin dependent diabetes; Exploration; Hemoglobin A1
• ISSN: 0143-5221; 1470-8736
• DOI: 10.1042/cs0880675

1. Semicarbazide-sensitive amine oxidase is a common name for a group of heterogeneous amine oxidases which are present in various mammalian tissues, especially in vascular smooth muscle cells, cartilage and adipose tissue, but also in plasma. 2. Plasma semicarbazide-sensitive amine oxidase activity was elevated in a group of 104 patients with insulin-dependent diabetes mellitus compared with normal control subjects (555 ± 172 versus 352 ± 102 m-units/l, P < 0.0005). 3. Plasma semicarbazide-sensitive amine oxidase activity was higher in subgroups with either retinopathy or nephropathy or both [583 ± 116 (n = 34), 581 ± 229 (n = 10) and. 646 ± 249 m-units/l (n = 19), respectively] than in the subgroup without overt complications [486 ± 129 m-units/l (n = 41), P < 0.005]. 4. Plasma semicarbazide-sensitive amine oxidase activity was positively correlated with plasma glycosylated haemoglobin (r = 0.40; P < 0.0001) and with log urinary albumin excretion (r = 0.26; P < 0.025). 5. The possibility that semicarbazide-sensitive amine oxidase, by its conversion of endogenous amines like methylamine and aminoacetone into cytotoxic aldehydes, plays a role in the development of microvascular complications in diabetes mellitus, needs further investigation.