Immunity of cholera in man: Relative role of antibacterial versus antitoxic immunity

Purified cholera toxoid is antigenic when given enterally and orally. Purified toxoid fails to provide protection against experimental challenge. Clinical cholera confers formidable protection against homologous or heterologous rechallenge. Failure to culture vibrios from intestinal fluid or stool o...

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Bibliographic Details
Published inTransactions of the Royal Society of Tropical Medicine and Hygiene Vol. 73; no. 1; pp. 3 - 9
Main Authors Levine, Myron M., Nalin, David R., Craig, John P., Hoover, David, Bergquist, Eric J., Waterman, Daniel, Holley, H.Preston, Hornick, Richard B., Pierce, Nathaniel P., Libonati, Joseph P.
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 1979
Royal Society of Tropical Medicine and Hygiene
Subjects
Antibodies, Bacterial - analysis
Antitoxins - analysis
Cholera - immunology
Cholera - prevention & control
Cholera Toxin - administration & dosage
Cholera Toxin - immunology
Humans
Immunization Schedule
Immunoglobulins - analysis
Intestinal Secretions - immunology
Vibrio cholerae - immunology
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Summary:Purified cholera toxoid is antigenic when given enterally and orally. Purified toxoid fails to provide protection against experimental challenge. Clinical cholera confers formidable protection against homologous or heterologous rechallenge. Failure to culture vibrios from intestinal fluid or stool of re-challenge volunteers suggests that the predominant immune mechanism is antibacterial rather than antitoxic.
Bibliography:istex:82892FC3DCBD8F0C685AEF7C084B18A605BDE792
ark:/67375/HXZ-WFXZNC1D-0
ISSN:0035-9203
1878-3503
DOI:10.1016/0035-9203(79)90119-6