Synthesis and Cerebrovascular Activity of Nicotinoyl-L-Proline

The cerebrovascular activity of the new synthesized compound nicotinoyl- L -proline in rats with acute ischemia caused by occlusion of the left carotid artery and chronic ischemia of the brain caused by hypokinesia of the animals was revealed. Laser Doppler flowmetry found that intraperitoneal admin...

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Bibliographic Details
Published inPharmaceutical chemistry journal Vol. 56; no. 2; pp. 159 - 162
Main Authors Aghamalyan, I. H., Karamyan, S. T., Balasanyan, M. G.
Format Journal Article
LanguageEnglish
Published New York Springer US 01.05.2022
Springer
Subjects
Heart beat
Ischemia
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
Proline
proline
hypokinesia
nicotinoyl
brain blood flow
cerebral ischemia
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Summary:The cerebrovascular activity of the new synthesized compound nicotinoyl- L -proline in rats with acute ischemia caused by occlusion of the left carotid artery and chronic ischemia of the brain caused by hypokinesia of the animals was revealed. Laser Doppler flowmetry found that intraperitoneal administration of the investigated nicotinoyl- L -proline at a dose of 10 mg/kg stimulated local cerebral blood flow by greater than 40% under both acute brain ischemia and chronic ischemia caused by hypokinesia of the animals during 15 d. Registration of systemic arterial pressure by the noninvasive tail–cuff method demonstrated that the effects of nicotinoyl- L -proline on cerebral blood flow were not accompanied by changes in the systolic and diastolic pressures and the heart rate.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-022-02615-0