The role of predictive vaginal biomarkers in women with cervical cerclage

Cervical cerclage is currently one of the primary methods of treatment for cervical insufficiency (CI). Identifying methods in order to selectively apply cerclage may allow us to further limit unnecessary procedures. In this regard, a limited number of inflammatory and extracellular matrix biomarker...

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Published inThe journal of maternal-fetal & neonatal medicine Vol. 31; no. 13; p. 1792
Main Authors Kanninen, Tomi T, Sisti, Giovanni, Di Tommaso, Mariarosaria, Berghella, Vincenzo
Format Journal Article
LanguageEnglish
Published England 03.07.2018
Subjects
Biomarkers - analysis
Cerclage, Cervical - methods
Female
Fibronectins - analysis
Humans
Interleukin-8 - analysis
Obstetric Labor, Premature - prevention & control
Predictive Value of Tests
Pregnancy
Uterine Cervical Incompetence - diagnosis
Uterine Cervical Incompetence - therapy
Vagina - physiopathology
cervical insufficiency
Cerclage
biomarkers
preterm delivery
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Summary:Cervical cerclage is currently one of the primary methods of treatment for cervical insufficiency (CI). Identifying methods in order to selectively apply cerclage may allow us to further limit unnecessary procedures. In this regard, a limited number of inflammatory and extracellular matrix biomarkers measurable non-invasively at the level of the cervix have been examined. In this review we summarize the current research on the use of cervical biomarkers in predicting cerclage failure and propose potential objectives for future research.
ISSN:1476-4954
DOI:10.1080/14767058.2017.1326895