Blood pressure response is impaired in patients with exercise-induced ventricular ectopy

• Published in: Journal of the American Society of Hypertension Vol. 10; no. 5; pp. 447 - 456
• Main Authors: Turan, Oguzhan Ekrem, MD, Ozturk, Mustafa, MD, Kocaoglu, Ibrahim, MD, Turan, Selen Gursoy, MD
• Format: Journal Article
• Language: English
• Published: United States 01.05.2016
• Subjects: Adult; Blood Pressure - physiology; Cardiovascular; Echocardiography; Electrocardiography; Exercise Test; Female; Humans; Male; Middle Aged; Prognosis; Retrospective Studies; Systole; Ventricular Premature Complexes - mortality; Ventricular Premature Complexes - physiopathology; exercise; Blood pressure; ventricular ectopy
• ISSN: 1933-1711; 1878-7436
• DOI: 10.1016/j.jash.2016.03.179

Abstract Exercise-induced ventricular ectopy (EIVE) has clinical and prognostic significance. But the mechanism underlying EIVE-related mortality still remains unclear. This study aims to assess blood pressure alteration in patients with EIVE and to identify the potential causes of increased mortality in this patient group. A total number of 3611 patients were screened within a 1-year period, and patients with a structural heart disease, coronary artery disease, hypertension, diabetes mellitus, thyroid dysfunction, and chronic renal disease were excluded from the study. A total number of 98 patients with no chronic disease, who were retrospectively diagnosed with EIVE, were included in the study as patient group and 116 patients without EIVE were included as control group. The median age, gender distribution, laboratory test results, and echocardiographic findings were similar between the two groups. Systolic blood pressure (SBP) alterations during exercise stress testing were found to be significantly different ( P  < .001). Moreover, EIVE group had significantly higher peak SBP ( P  < .001). A significant positive relation was found between peak SBP level and ventricular ectopy count (r:0.27, P  = .006). Our study showed that EIVE patients without a structural heart disease or a chronic disease had higher peak SBP levels. Higher SBP alteration can be related to ventricular ectopy occurrence during exercise stress testing, which can be a possible reason underlying the increased rate of mortality among EIVE patients.