Atypical Teratoid Rhabdoid Tumor in a Newborn: Can IVF Be a Risk Factor?

• Published in: Fetal and pediatric pathology Vol. 41; no. 4; pp. 1 - 669
• Main Authors: Rzayev, Turkay, Gokce, Kubra, Gucyetmez, Safak, Bozkurt, Suheyla, Dagcinar, Adnan, Tokuc, Gulnur, Yaman, Akan, Bilgen, Hulya, Ozek, Eren
• Format: Journal Article
• Language: English
• Published: England 04.07.2022
• Subjects: in vitro fertilization; Atypical teratoid rhabdoid tumor; newborn
• ISSN: 1551-3815; 1551-3823
• DOI: 10.1080/15513815.2021.1913536

In recent years, with the widespread use of assisted reproductive technologies, questions have arisen regarding the possible relationship between these infertile parents with assisted conception procedures and childhood cancers. We present a 23-day-old newborn conceived by in vitro fertilization (IVF) with a 53 × 46 × 38 mm intracranial mass detected by magnetic resonance imaging on the 15th postnatal day. The mass, removed on 23rd postnatal day, was an Atypical Teratoid Rhabdoid Tumor (ATRT), WHO grade 4. As far as we know, this is the only neonatally detected ATRT. Further studies are needed to investigate whether there is a causal relationship between IVF and childhood cancers.