Primary intracerebral small-cell osteosarcoma in an adolescent girl : report of a case

• Published in: Journal of neuro-oncology Vol. 32; no. 2; pp. 169 - 174
• Main Authors: SIPOS, E. P, TAMARGO, R. J, EPSTEIN, J. I, NORTH, R. B
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer 01.04.1997; Springer Nature B.V
• Subjects: Adolescent; Antineoplastic Agents - therapeutic use; Biological and medical sciences; Bleomycin - therapeutic use; Bone cancer; Brain cancer; Brain Neoplasms - pathology; Brain Neoplasms - surgery; Brain Neoplasms - therapy; Case reports; Chemotherapy; Chemotherapy, Adjuvant; Cisplatin - therapeutic use; Computed tomography; Cyclophosphamide - therapeutic use; Dactinomycin - therapeutic use; Diseases of the osteoarticular system; Doxorubicin - therapeutic use; Female; Headache; Humans; Magnetic Resonance Imaging; Medical sciences; Metastases; Optic nerve; Osteosarcoma; Osteosarcoma - pathology; Osteosarcoma - surgery; Osteosarcoma - therapy; Parietal lobe; Patients; Radiation therapy; Radiotherapy, Adjuvant; Sarcoma; Swelling; Therapeutic applications; Thorax; Tumors of striated muscle and skeleton; Human; Antineoplastic agent; Intracranial; Nervous system diseases; Diseases of the osteoarticular system; Malignant tumor; Radiotherapy; Cerebral disorder; Case study; Chemotherapy; Osteosarcoma; Central nervous system disease; Adolescent; Primary; Evolution; Female; Bone
• ISSN: 0167-594X; 1573-7373
• DOI: 10.1023/A:1005775818317

A young patient surviving four years after treatment for primary intracerebral small-cell osteosarcoma is reported. This 16-year-old girl presented with headaches, visual disturbance, and papilledema and was found to have a large, heavily calcified mass in the left parietal lobe. A gross total resection of the tumor was performed and pathologic analysis revealed a small-cell osteosarcoma. Thoracic computerized tomography (CT) scans and a complete bone scan showed no other lesions. The patient received adjuvant chemotherapy and radiotherapy. She continues to do well with no evidence of metastases or local recurrence 4 years after her initial presentation. The clinical, radiographic, surgical, pathologic, and immunohistochemical features of this case, along with therapeutic interventions and outcome, are presented.