A Rare Case of Aggressive Atypical Cervical Cancer With Multi-Organ Involvement

Squamous cell carcinoma (SCC) of cervical origin with metastasis to the brain is rare. Our patient was a 30-year-old Caucasian female with squamous cell carcinoma, initially with unknown primary, with metastases to the brain, kidney, cervix, lung, adrenal glands, vulva, pelvic wall, and scalp. She i...

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Published inCurēus (Palo Alto, CA) Vol. 14; no. 12; p. e32968
Main Authors Hernandez, Carina, Glidden, Alanna, Sandhu, Michael, Agrawal, Kavita, Caicedo Murillo, Martha, Heritage, Claudia, Ramovic, Merima, Akhtar, Komal
Format Journal Article
LanguageEnglish
Published United States Cureus Inc 26.12.2022
Cureus
Subjects
Adrenal glands
Antigens
Back pain
Biopsy
Brain cancer
Cancer therapies
Case reports
Cervical cancer
Cervix
Edema
Human papillomavirus
Immunotherapy
Medical prognosis
Medical screening
Metastasis
Monoclonal antibodies
Oncology
Pathology
Pulmonary arteries
Radiation
Spinal cord
Squamous cell carcinoma
Targeted cancer therapy
Tumors
brain metastasis
multi-organ
cervical cancer
hpv
squamous cell carcinoma
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Summary:Squamous cell carcinoma (SCC) of cervical origin with metastasis to the brain is rare. Our patient was a 30-year-old Caucasian female with squamous cell carcinoma, initially with unknown primary, with metastases to the brain, kidney, cervix, lung, adrenal glands, vulva, pelvic wall, and scalp. She initially presented to her outpatient gynecologist for a vulvar mass. A biopsy of the vulvar mass was consistent with SCC. The patient continued to have fatigue along with thoracic rib pain. An initial work-up was performed, including imaging which showed diffuse metastatic disease involving the lungs, kidneys and adrenal glands, as well as a pathological compression fracture of the seventh thoracic vertebra with cord compression. Brain magnetic resonance imaging (MRI) showed multiple metastatic lesions and she underwent craniotomy for brain lesion resection. Given the aggressive nature of the patient's disease and her symptomatic burden, she was started on chemotherapy in the hospital with Carboplatin, Paclitaxel, and Pembrolizumab.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.32968