Genotoxic potential of cyclosporin A in patients with renal transplantation

• Published in: Cell biology and toxicology Vol. 15; no. 1; pp. 13 - 17
• Main Authors: PALANDUZ, S, SEVER, M. S, ÖZTÜRK, S, TASCIOGLU, C, KARAN, M. A, SÖNMEZ, G, CEFLE, K, GÜLER, K
• Format: Conference Proceeding Journal Article
• Language: English
• Published: Dordrecht Springer 01.02.1999; Springer Nature B.V
• Subjects: Adolescent; Adult; Biological and medical sciences; Cells, Cultured; Cyclosporine - adverse effects; Drug toxicity and drugs side effects treatment; Female; Genes; Humans; Immunosuppressive Agents - adverse effects; Kidney Transplantation; Lymphocytes; Lymphocytes - drug effects; Male; Medical sciences; Middle Aged; Miscellaneous (drug allergy, mutagens, teratogens...); Pharmacology. Drug treatments; Sister Chromatid Exchange - drug effects; Kidney disease; Human; Potentiation; Toxicity; Sister chromatid exchange; Biological marker; Time response relation; Transplantation; Mutagen; In vivo; Gene; DNA; Ciclosporin; Immunosuppressive agent; Lymphocyte

We analyzed the induction of sister chromatid exchange (SCE) by cyclosporin A (CsA) as a marker of genotoxic potential. In 30 patients undergoing renal transplantation, SCE induction was tested before the introduction of CsA and 3 months later. We found that SCE frequency increased significantly at...