Genotoxic potential of cyclosporin A in patients with renal transplantation

We analyzed the induction of sister chromatid exchange (SCE) by cyclosporin A (CsA) as a marker of genotoxic potential. In 30 patients undergoing renal transplantation, SCE induction was tested before the introduction of CsA and 3 months later. We found that SCE frequency increased significantly at...

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Bibliographic Details
Published inCell biology and toxicology Vol. 15; no. 1; pp. 13 - 17
Main Authors PALANDUZ, S, SEVER, M. S, ÖZTÜRK, S, TASCIOGLU, C, KARAN, M. A, SÖNMEZ, G, CEFLE, K, GÜLER, K
Format Conference Proceeding Journal Article
LanguageEnglish
Published Dordrecht Springer 01.02.1999
Springer Nature B.V
Subjects
Adolescent
Adult
Biological and medical sciences
Cells, Cultured
Cyclosporine - adverse effects
Drug toxicity and drugs side effects treatment
Female
Genes
Humans
Immunosuppressive Agents - adverse effects
Kidney Transplantation
Lymphocytes
Lymphocytes - drug effects
Male
Medical sciences
Middle Aged
Miscellaneous (drug allergy, mutagens, teratogens...)
Pharmacology. Drug treatments
Sister Chromatid Exchange - drug effects
Kidney disease
Human
Potentiation
Toxicity
Sister chromatid exchange
Biological marker
Time response relation
Transplantation
Mutagen
In vivo
Gene
DNA
Ciclosporin
Immunosuppressive agent
Lymphocyte
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Summary:We analyzed the induction of sister chromatid exchange (SCE) by cyclosporin A (CsA) as a marker of genotoxic potential. In 30 patients undergoing renal transplantation, SCE induction was tested before the introduction of CsA and 3 months later. We found that SCE frequency increased significantly at the end of 3 months. To our knowledge, this is the first study demonstrating in vivo induction of SCE by CsA in humans. We conclude that CsA has a genotoxic potential on human lymphocytes.
ISSN:0742-2091
1573-6822
DOI:10.1023/A:1007594421458