The pharmacological effect of polysaccharides from Lentinus edodes on the oxidative status and expression of VCAM-1mRNA of thoracic aorta endothelial cell in high-fat-diet rats
The aim of this study was to investigate the pharmacological effect of polysaccharides from Lentinus edodes on serum oxidative status and expression of VCAM-1mRNA of thoracic aorta endothelial cell in high-fat-diet rats. Forty male rats received two different diets during 40 days: standard chow (SC)...
Saved in:
Published in | Carbohydrate polymers Vol. 74; no. 3; pp. 445 - 450 |
---|---|
Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Oxford
Elsevier Ltd
01.11.2008
Elsevier Science |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | The aim of this study was to investigate the pharmacological effect of polysaccharides from
Lentinus edodes on serum oxidative status and expression of VCAM-1mRNA of thoracic aorta endothelial cell in high-fat-diet rats. Forty male rats received two different diets during 40 days: standard chow (SC) and high-fat-diet (HF). The result indicates that the administration of polysaccharides from
L. edodes significantly reduced serum total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-c) and enhanced serum antioxidant enzyme activity and thymus and liver index in high-fat rats. In addition, the administration of polysaccharides from
L. edodes significantly decreased the increased expression level of VCAM-1mRNA in group (V) (
P
<
0.05). In conclusion, our data suggest that the administration of polysaccharides from
L. edodes could decrease the increased oxidation stress induced by high-fat-diet and decrease expression of VCAM-1mRNA of thoracic aorta endothelial cell in rats. |
---|---|
Bibliography: | http://dx.doi.org/10.1016/j.carbpol.2008.03.018 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0144-8617 1879-1344 |
DOI: | 10.1016/j.carbpol.2008.03.018 |