The pharmacological effect of polysaccharides from Lentinus edodes on the oxidative status and expression of VCAM-1mRNA of thoracic aorta endothelial cell in high-fat-diet rats

• Published in: Carbohydrate polymers Vol. 74; no. 3; pp. 445 - 450
• Main Authors: Xu, Chen, HaiYan, Zhong, JianHong, Zeng, Jing, Ge
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01.11.2008; Elsevier Science
• Subjects: anticholesteremic agents; Applied sciences; Biological and medical sciences; cholesterol; Exact sciences and technology; gene expression; General and cellular metabolism. Vitamins; High-fat-diet; Lentinula edodes; low density lipoprotein; Medical sciences; medicinal properties; mushrooms; Natural polymers; Pharmacology. Drug treatments; Physicochemistry of polymers; polysaccharides; Polysaccharides from Lentinus edodes; Rat; rats; SOD; Starch and polysaccharides; superoxide dismutase; triacylglycerols; Polysaccharides from Lentinus edodes; SOD; TG; Rat; High-fat-diet; TC; Oxidative stress; Endothelial cell; Unbalanced diet; Rodentia; Cell adhesion molecule; Oral administration; Experimental study; Gene expression; Biological activity; Basidiomycota; Lentinus edodes; Fungi; Vertebrata; Mammalia; Animal; Plant origin; Oside polymer
• ISSN: 0144-8617; 1879-1344
• DOI: 10.1016/j.carbpol.2008.03.018

The aim of this study was to investigate the pharmacological effect of polysaccharides from Lentinus edodes on serum oxidative status and expression of VCAM-1mRNA of thoracic aorta endothelial cell in high-fat-diet rats. Forty male rats received two different diets during 40 days: standard chow (SC) and high-fat-diet (HF). The result indicates that the administration of polysaccharides from L. edodes significantly reduced serum total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-c) and enhanced serum antioxidant enzyme activity and thymus and liver index in high-fat rats. In addition, the administration of polysaccharides from L. edodes significantly decreased the increased expression level of VCAM-1mRNA in group (V) ( P < 0.05). In conclusion, our data suggest that the administration of polysaccharides from L. edodes could decrease the increased oxidation stress induced by high-fat-diet and decrease expression of VCAM-1mRNA of thoracic aorta endothelial cell in rats.