Detection of blood cancer using highly sensitive surface plasmon resonance sensor based on MXene 2D nanomaterial

• Published in: Diamond and related materials Vol. 137; p. 110142
• Main Authors: Almawgani, Abdulkarem H.M., Daher, Malek G., Taya, Sofyan A., Hindi, Ayman Taher, Colak, Ilhami, Pal, Amrindra
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.08.2023
• Subjects: Blood cancer; MXene; Sensitivity; Surface plasmon resonance; Transfer matrix technique; Sensitivity; Surface plasmon resonance; Blood cancer; Transfer matrix technique; MXene
• ISSN: 0925-9635; 1879-0062
• DOI: 10.1016/j.diamond.2023.110142

The most common disease on the earth, cancer, has raised concerns about the health of humans. Early discovery is a crucial argument to increase treatment success. A surface plasmon resonance (SPR) biosensor having prism, silver, MXene and analyte is theoretically proposed and numerically simulated in this work for rapid and accurate detection of blood cancer cells. Many different prisms are examined. The structure with the lowest refractive index prism has shown the highest sensitivity, hence it is taken into consideration for additional studies. Since an MXene layer has a larger surface area, it enhances surface-biomolecule adsorption. The number of MXene sheets and silver layer thickness are optimized to improve the sensor sensitivity. The SPR sensor can attain a sensitivity of 232.25 deg/RIU for 50 nm silver with a bi-layer of MXene. We believe that the proposed sensor has a very simple structure to facilitate the fabrication and it will be encouraging to be used in biosensing. [Display omitted] •A surface plasmon resonance (SPR)-based sensor is proposed for blood cancer detection.•The findings demonstrate that the proposed sensor is more sensitive with an MXene layer.•The structure with the lowest refractive index prism has shown the highest sensitivity.•The SPR sensor can attain a sensitivity of 232.25 deg/RIU for 50 nm silver with a bi-layer of MXene.