The role of chemokines and chemokine receptors in alloantigen-independent and alloantigen-dependent transplantation injury

• Published in: Seminars in immunology Vol. 15; no. 1; pp. 33 - 48
• Main Authors: DeVries, Mark E, Hosiawa, Karoline A, Cameron, Cheryl M, Bosinger, Steven E, Persad, Desmond, Kelvin, Alyson A, Coombs, Jeff C, Wang, Hao, Zhong, Robert, Cameron, Mark J, Kelvin, David J
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.02.2003
• Subjects: Animals; Antibodies, Monoclonal - immunology; Antibodies, Monoclonal - pharmacology; Chemokine receptors; Chemokines; Chemokines - immunology; Chronic Disease; Gene Expression Profiling; Graft Rejection - drug therapy; Graft Rejection - genetics; Graft Rejection - immunology; Graft Rejection - pathology; Humans; Immunity, Cellular - drug effects; Immunity, Cellular - immunology; Isoantigens - immunology; Microarray; Receptors, Chemokine - immunology; Transplantation; Transplantation Immunology; Transplantation injury; Viral Proteins - therapeutic use; Transplantation; Microarray; Chemokines; Chemokine receptors; Transplantation injury
• ISSN: 1044-5323; 1096-3618
• DOI: 10.1016/S1044-5323(02)00126-4

Transplantation injury and rejection involves the interplay of innate and acquired immune responses. Immune-related injury manifests itself in three temporal phases: early innate immune driven alloantigen-independent injury, acquired immune driven alloantigen-dependent injury, and chronic injury. Sequential waves of chemokine expression play a central role in regulating graft injury through the recruitment of phagocytes shortly after transplantation and activated lymphocytes and phagocytes in the weeks and years following transplantation. This review focuses on recent studies demonstrating the role of chemokines in transplantation.