The prognostic value of regulatory T cells infiltration in HER2-enriched breast cancer microenvironment

Breast cancer represents a complex and heterogeneous disease that comprises distinct disease conditions, histological features, and clinical outcome. Since many years, it has been demonstrated as an association between HER2 amplification and poor prognosis, because its overexpression is associated w...

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Published inInternational reviews of immunology Vol. 37; no. 3; pp. 144 - 150
Main Authors Banin-Hirata, Bruna K, de Oliveira, Carlos E C, Losi-Guembarovski, Roberta, Ozawa, Patricia M M, Vitiello, Glauco A F, de Almeida, Felipe C, Derossi, Daniela R, André, Nayara D, Watanabe, Maria A E
Format Journal Article
LanguageEnglish
Published England 04.05.2018
Subjects
Animals
Biomarkers, Tumor - metabolism
Breast Neoplasms - diagnosis
Breast Neoplasms - immunology
Carcinogenesis
Cell Movement
Female
Humans
Predictive Value of Tests
Prognosis
Receptor, ErbB-2 - metabolism
T-Lymphocytes, Regulatory - immunology
Tumor Microenvironment
Breast cancer
lymphocyte infiltration
HER2 overexpression
Tregs
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Summary:Breast cancer represents a complex and heterogeneous disease that comprises distinct disease conditions, histological features, and clinical outcome. Since many years, it has been demonstrated as an association between HER2 amplification and poor prognosis, because its overexpression is associated with an aggressive phenotype of breast tumor cells. A significant proportion of cases have developed resistance to the current therapies available. Consequently, new prognostic markers are urgently needed to identify patients who are at the highest risk for developing metastases. During the past decade, new insights provided valuable knowledge regarding mechanisms underlying the dynamic interplayed between immune cells and tumor progression. It has been shown that the presence of a lymphocytic infiltrate, particularly of regulatory T cells, in cancer tissue, is associated with clinical outcome promoting rather than inhibiting cancer development and progression. It has been also verified that the clinical value of lymphocytic infiltration in breast cancers could be subtype-dependent, including the HER2-enriched subtype. In this context, this work summarizes proposed to discuss the prognostic value of regulatory T cell infiltration in microenvironment of HER2-enriched breast cancer.
ISSN:0883-0185
1563-5244
DOI:10.1080/08830185.2017.1401620