Effects of Chemotherapy on Fertility Preservation in Patients with Tumors of the Hematopoietic and Lymphoid Tissues

Fertility preservation is an important concern for young cancer patients. Oocyte or embryo cryopreservation prior to chemotherapy administration is desirable but often difficult for patients with hematopoietic and lymphoid tissue tumors. In this study, we examined the results of fertility preservati...

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Published inReproductive medicine (Basel, Switzerland) Vol. 3; no. 2; pp. 141 - 149
Main Authors Akino, Ryosuke, Nishii, Shogo, Odawara, Kei, Saito, Megumi, Sakamoto, Miwa, Kondo, Tetsuro, Sekizawa, Akihiko
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.06.2022
Subjects
Breast cancer
Cancer therapies
Chemotherapy
Clinical outcomes
Cryopreservation
Eggs
Fertility
fertility preservation
Leukemia
Lymphoma
malignant lymphoma
oocyte cryopreservation
Ovaries
Patients
Radiation therapy
Remission (Medicine)
Statistical analysis
Stem cell transplantation
Tumors
New York
United States > US
Japan
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Summary:Fertility preservation is an important concern for young cancer patients. Oocyte or embryo cryopreservation prior to chemotherapy administration is desirable but often difficult for patients with hematopoietic and lymphoid tissue tumors. In this study, we examined the results of fertility preservation therapy in patients with hematopoietic and lymphoid tissue tumors. We retrospectively examined hematopoietic and lymphoid tissue tumors of five patients who underwent oocyte cryopreservation as a fertility preservation therapy after chemotherapy, at Showa University Hospital from February 2017 to September 2020. Eleven treatment cycles were administered (one of which was cancelled). The mean age of the patients was 28.6 years. The mean controlled ovarian stimulation duration for 10 cycles was 15.9 days, the mean total gonadotropin dose was 3705 IU, and the mean peak E2 was 502.8 (pg/mL). The mean number of eggs retrieved was 3.2, the mean number of mature oocytes was 2.1, and the mean maturation rate (mature oocytes/returned oocytes) was 70.7%. Fertility preservation procedures in the early period after chemotherapy may be viable because they allow for the acquisition of mature oocytes, even though the procedures may take longer and yield fewer oocytes.
ISSN:2673-3897
2673-3897
DOI:10.3390/reprodmed3020012