Grafting of 4-aminomethylbenzensulfonamide-lipoic acid conjugate on gold nanoparticles

In this paper, we describe the synthesis of goldnanoparticles bearing aminomethylbenzensulfonamide via a lipoyl moiety. The resulting stable nanoparticles with an average size of 4.0 nm have been achieved by a facile and high-yielding one phase method, by the action of 4-aminomethylbenzensulfonamide...

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Published inIOP conference series. Materials Science and Engineering Vol. 28; no. 1; pp. 12032 - 8
Main Authors Stiti, M, Bouzit, H, Abdaoui, M, Winum, J Y
Format Journal Article
LanguageEnglish
Published Bristol IOP Publishing 01.01.2012
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Summary:In this paper, we describe the synthesis of goldnanoparticles bearing aminomethylbenzensulfonamide via a lipoyl moiety. The resulting stable nanoparticles with an average size of 4.0 nm have been achieved by a facile and high-yielding one phase method, by the action of 4-aminomethylbenzensulfonamide-lipoic acid bioconjugate on chloroauric acide, using dimethylsulfoxide (DMSO) as the solvent and sodium tetrahydridoborate (NaBH4) as the reducing agent. UV-vis absorption, transmission electron microscopy (TEM) and X-ray diffraction were used to analyse the morphology and the structure of the obtained nanoparticles. Preliminary study shows that these new nanoparticles are endowed with highly and specific inhibitory activity for the isoform (IX) of carbonic anhydrase over expressed in many cancers, and are therefore attractive candidate to be used both in diagnosis and in treatment of tumours.
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ISSN:1757-899X
1757-8981
1757-899X
DOI:10.1088/1757-899X/28/1/012032