Disseminated intravascular coagulation and purpura fulminans secondary to infection

• Published in: Bailliere's best practice & research. Clinical haematology Vol. 13; no. 2; pp. 179 - 197
• Main Authors: Faust, Saul N, Heyderman, Robert S, Levin, Michael
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.06.2000
• Subjects: antithrombin (ATIII); Bacterial Infections - complications; Blood Coagulation Factors - metabolism; clinical trials; Cytokines - adverse effects; Cytokines - secretion; disseminated intravascular coagulation (DIC); Disseminated Intravascular Coagulation - etiology; Disseminated Intravascular Coagulation - metabolism; Disseminated Intravascular Coagulation - therapy; Gram-negative; Humans; meningococcal; pathophysiology; protein C (PC)/activated protein C (APC); purpura fulminans; Purpura, Schoenlein-Henoch - etiology; Purpura, Schoenlein-Henoch - metabolism; Purpura, Schoenlein-Henoch - therapy; therapy; thrombomodulin (TM); tissue factor (TF); tissue factor pathway inhibitor (TFPI); tissue plasminogen activator (tPA); tissue factor (TF); purpura fulminans; therapy; Gram-negative; protein C (PC)/activated protein C (APC); antithrombin (ATIII); meningococcal; thrombomodulin (TM); tissue plasminogen activator (tPA); disseminated intravascular coagulation (DIC); pathophysiology; clinical trials; tissue factor pathway inhibitor (TFPI)
• ISSN: 1521-6926; 1532-1924
• DOI: 10.1053/beha.2000.0067

Infection is one of the commonest causes of disseminated intravascular coagulation (DIC). DIC is a complex disorder that results from an imbalance of the pro- and anticoagulant regulatory pathways. This chapter will explain the cellular and molecular basis of the disorder and consider the rationale behind current and experimental treatment strategies.