Effect of 6-Azathymine, an analog of thymine, on the urinary excretion of uracil

The administration of 6-azathymine, an analog of thymine, to mice resulted in the excretion of large amounts of uracil in urine. 6-Azathymine and 5-bromo-6-azauracil, but not 6-azauracil, 5-ethyl-6-azauracil or 5- n-propyl-6-azauracil inhibited the degradation of uracil by a particle-free fraction o...

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Published inBiochimica et biophysica acta Vol. 61; no. 1; pp. 81 - 85
Main Authors Prusoff, William H., Gaito, Raymond A.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 09.07.1962
Subjects
Nucleosides - pharmacology
Nucleotides - pharmacology
Old Medline
Organic Chemicals
Thymine
Uracil - urine
NUCLEOSIDES AND NUCLEOTIDES/pharmacology
URACIL/urine
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Summary:The administration of 6-azathymine, an analog of thymine, to mice resulted in the excretion of large amounts of uracil in urine. 6-Azathymine and 5-bromo-6-azauracil, but not 6-azauracil, 5-ethyl-6-azauracil or 5- n-propyl-6-azauracil inhibited the degradation of uracil by a particle-free fraction of rat liver. The enzymic degradation of uracil was inhibited by 6-azathymine to a greater extent then thymine.
Bibliography:ObjectType-Article-1
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ISSN:0926-6550
0006-3002
1878-2256
DOI:10.1016/0926-6550(62)90033-6