Effect of imidazobenzoimidazole derivatives RU-353, RU-563, and lidocaine on cerebral circulation in rats

We demonstrated a dose-dependent inhibitory effect of novel imidazobenzoimidazole derivatives RU-353 and RU-563 on cerebral blood flow and systemic blood pressure in narcotized rats. The effects of RU-353 increased, while the effect of RU-563 decreased with increasing the dose.

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Bibliographic Details
Published inBulletin of experimental biology and medicine Vol. 139; no. 4; pp. 418 - 420
Main Authors Galenko-Yaroshevskii, A P, Turovaya, A Yu, Uvarov, A V, Prikhod'ko, A K, Ivashev, M N, Arl't, A V, Anisimova, V A
Format Journal Article
LanguageEnglish
Published United States Springer Nature B.V 01.04.2005
Subjects
Animals
Benzimidazoles - pharmacology
Cerebrovascular Circulation - drug effects
Dose-Response Relationship, Drug
Lidocaine - pharmacology
Male
Rats
Rats, Wistar
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Summary:We demonstrated a dose-dependent inhibitory effect of novel imidazobenzoimidazole derivatives RU-353 and RU-563 on cerebral blood flow and systemic blood pressure in narcotized rats. The effects of RU-353 increased, while the effect of RU-563 decreased with increasing the dose.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-005-0310-6