Activation of the resting periosteum

A single para osteal injection of an aqueous extract of immature bovine bone doubles the diameter of the rat radius and ulna, within 7 days. Bone is formed by activation and prolifeation of cells in the cambium layer of the periosteum. The fibrous periosteum remains intact and appears to adapt by st...

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Bibliographic Details
Published inClinical orthopaedics and related research no. 129; p. 305
Main Authors Tornberg, D N, Bassett, C A
Format Journal Article
LanguageEnglish
Published United States 01.11.1977
Subjects
Animals
Bone and Bones
Bone Regeneration
Cattle
Cell Differentiation
Models, Biological
Osteogenesis
Periosteum - cytology
Rats
Tissue Extracts - pharmacology
Wound Healing
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Summary:A single para osteal injection of an aqueous extract of immature bovine bone doubles the diameter of the rat radius and ulna, within 7 days. Bone is formed by activation and prolifeation of cells in the cambium layer of the periosteum. The fibrous periosteum remains intact and appears to adapt by stretching. New trabeculae are oriented radailly about the diphyses. The organic matrix, mainly new bone collagen is elaborated primarly during the first 72 hours and mineralized, in the last 4 days of study. The response is interpreted as an example of cell activation, rather than osteogenic induction and demonstrates tha rapid and massive osteogensis can be trigegered by an appropriate exogenous stimulus.
ISSN:0009-921X
DOI:10.1097/00003086-197711000-00043