Interrogating the kinome

• Published in: Nature biotechnology Vol. 29; no. 11; pp. 981 - 983
• Main Authors: Zhang, Chao, Habets, Gaston, Bollag, Gideon
• Format: Journal Article
• Language: English
• Published: United States Nature Publishing Group 08.11.2011
• Subjects: Biotechnology; Catalysis; Drug Design; High-Throughput Screening Assays; Humans; Kinases; Pharmaceutical industry; Pharmacology; Protein Kinase Inhibitors - chemistry; Protein Kinases - chemistry

Comprehensive studies of the kinome are setting the stage for discovering the next generation of kinase-directed drugs. Zhang et al common on the work of Anastassiadis et al and Davis et al which provides a comprehensive resource that can be mined to discover unexpected interactions, shared chemotyp...