Interrogating the kinome

Comprehensive studies of the kinome are setting the stage for discovering the next generation of kinase-directed drugs. Zhang et al common on the work of Anastassiadis et al and Davis et al which provides a comprehensive resource that can be mined to discover unexpected interactions, shared chemotyp...

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Bibliographic Details
Published inNature biotechnology Vol. 29; no. 11; pp. 981 - 983
Main Authors Zhang, Chao, Habets, Gaston, Bollag, Gideon
Format Journal Article
LanguageEnglish
Published United States Nature Publishing Group 08.11.2011
Subjects
Biotechnology
Catalysis
Drug Design
High-Throughput Screening Assays
Humans
Kinases
Pharmaceutical industry
Pharmacology
Protein Kinase Inhibitors - chemistry
Protein Kinases - chemistry
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Summary:Comprehensive studies of the kinome are setting the stage for discovering the next generation of kinase-directed drugs. Zhang et al common on the work of Anastassiadis et al and Davis et al which provides a comprehensive resource that can be mined to discover unexpected interactions, shared chemotype preferences of seemingly unrelated kinases, and structure-activity relationships among disparate inhibitor classes.
Bibliography:SourceType-Other Sources-1
ObjectType-News-1
ObjectType-Commentary-2
content type line 66
ISSN:1087-0156
1546-1696
DOI:10.1038/nbt.2021