The haplotype of SLC2A9_rs3733591, PKD2_rs2725220 and ABCG2_rs2231142 increases the hyperuricaemia risk and alcohol, chicken and processed meat intakes and smoking interact with its risk

• Published in: International journal of food sciences and nutrition Vol. 72; no. 3; pp. 391 - 401
• Main Authors: Yang, Hye Jeong, Liu, Meiling, Kim, Min Jung, Park, Sunmin
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 01.05.2021; Taylor & Francis Ltd
• Subjects: Alcohol; alcohol intake; Alcohols; Alleles; chicken intake; Chickens; Cigarette smoking; Drinking behavior; Food science; Gout; Gout risk; GWAS; Haplotypes; hyperuricaemia; Hyperuricemia; Meat; Nutrients; Poultry; Risk; Single-nucleotide polymorphism; Smoking; Gout risk; alcohol intake; GWAS; chicken intake; hyperuricaemia
• ISSN: 0963-7486; 1465-3478
• DOI: 10.1080/09637486.2020.1807474

We determined that a genetic haplotype increased the risk of hyperuricaemia and it interacted with lifestyle factors, including nutrients in 28,445 middle-aged Koreans. ABCG2_rs2231142, PKD2_rs2725220 and SLC2A9_rs3733591 were selected from GWAS based on hyperuricaemia (≥7 mg/dL; p = 6.88E-42, 1.56E-26 and 1.01E-20, respectively). Hyperuricaemia and gout were elevated by 3.93- and 3.23-fold, respectively, by the minor alleles as compared with the major alleles of the haplotype of the selected 3 SNPs after adjusting for covariates. The haplotype significantly interacted with alcohol, chicken and processed meat intakes, and smoking status in the hyperuricaemia risk (p = 0.002-0.007). Minor alleles of the haplotype had an association with hyperuricaemia as compared with major alleles particularly in high intakes of alcohol (2g/day), chicken (6.3g/day), and processed meat (3g/day) and smokers. In conclusion, people carrying minor alleles of the haplotype of SLC2A9_rs3733591, PKD2_rs2725220 and ABCG2_rs2231142 should avoid diets high in chicken and processed meat, alcohol drinking, and cigarette smoking to protect against hyperuricaemia risk.