Acetylcholine

Acetylcholine is the major excitatory neurotransmitter at nematode neuromuscular junctions, and more than a third of the cells in the C. elegans nervous system release acetylcholine. Through a combination of forward genetics, drug-resistance selections, and genomic analysis, mutants have been identi...

Full description

Saved in:
Bibliographic Details
Published inWormBook pp. 1 - 21
Main Author Rand, James B
Format Journal Article
LanguageEnglish
Published United States s.n. 30.01.2007
Subjects
Acetylcholine - biosynthesis
Acetylcholine - physiology
Acetylcholinesterase - metabolism
Animals
Biological Transport
Caenorhabditis elegans - drug effects
Caenorhabditis elegans - physiology
Caenorhabditis elegans Proteins - physiology
Choline - metabolism
Cytoplasmic Vesicles - physiology
Humans
Receptors, Cholinergic - genetics
Receptors, Cholinergic - metabolism
Online AccessGet full text

Cover

More Information
Summary:Acetylcholine is the major excitatory neurotransmitter at nematode neuromuscular junctions, and more than a third of the cells in the C. elegans nervous system release acetylcholine. Through a combination of forward genetics, drug-resistance selections, and genomic analysis, mutants have been identified for all of the steps specifically required for cholinergic function. These include two enzymes, two transporters, and a bewildering assortment of receptors. Cholinergic transmission is involved, directly or indirectly, in many C. elegans behaviors, including locomotion, egg laying, feeding, and male mating.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1551-8507
1551-8507
DOI:10.1895/wormbook.1.131.1