Heterogeneity of DNA Content According to the Depth of Invasion in Colorectal Cancer

Thirty-one cases of colorectal carcinoma were investigated for intratumor heterogeneity in DNA ploidy, DNA index, and S-phase fraction. DNA content of samples from the superficial layer and the deep layer in the same tumor was determined by flow cytometry. Heterogeneity of the DNA ploidy patternwas...

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Bibliographic Details
Published inNippon Shokaki Geka Gakkai zasshi Vol. 25; no. 11; pp. 2760 - 2764
Main Authors Imada, Toshio, Suda, Takashi, Kito, Fumihiko, Okada, Kenzo, Okada, Takako, Fukuzawa, Kuniyasu, Moriwaki, Yoshihiro, Akiyama, Hirotoshi, Takemura, Hiroshi, Matsumoto, Akihiko
Format Journal Article
LanguageEnglish
Japanese
Published The Japanese Society of Gastroenterological Surgery 1992
Subjects
DNA content of colorectal carcinoma
flow cytometry
heterogeneity
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Summary:Thirty-one cases of colorectal carcinoma were investigated for intratumor heterogeneity in DNA ploidy, DNA index, and S-phase fraction. DNA content of samples from the superficial layer and the deep layer in the same tumor was determined by flow cytometry. Heterogeneity of the DNA ploidy patternwas observed in 3 cases (9.7%). The DNA index was 2.18 and 2.11 and the S-phase fraction was 30.4% and 28.6% inthe superficial and deep layers, respectively. These data indicate a low degree of intratumoral heterogeneity of DNA content according to the depth of invasion in colorectal carcinoma.
ISSN:0386-9768
1348-9372
DOI:10.5833/jjgs.25.2760