Effects of Caulerpa lentillifera polysaccharides on immune function in vitro and in vivo

• Published in: Journal of food processing and preservation Vol. 46; no. 12
• Main Authors: Zhou, Bingxue, Nguyễn, Audrey D., Shen, Jinyang, Wu, Yi
• Format: Journal Article
• Language: English
• Published: 01.12.2022
• ISSN: 0145-8892; 1745-4549
• DOI: 10.1111/jfpp.17260

The immune enhancement effects of Caulerpa lentillifera polysaccharides (CLP) in vitro and in vivo were observed in this study. The results of the in vitro experiments show that CLP extract can promote the activation and maturation of dendritic cells and enhance the expression of IL‐6, TNF‐α, CD80, CD86, and MHC II. Expression of IL‐6 and TNF‐α was determined with ELISA kits, CD80 and CD86 were measured by flow cytometry, and MHC II was analyzed with a laser scanning confocal microscope. Changes in dendritic cell morphology and volume were also studied. The in vivo experiment shows that CLP can promote the secretion of IL‐6, INF‐γ, IgA, and IgG and enhance humoral and cellular immunity in mice. CLP extract's ability to upregulate immunity in vitro and in vivo makes it worthy of further investigation as an effective natural immunopotentiator. Novelty impact statement Caulerpa lentillifera polysaccharides could enhance immunity in vitro and in vivo. C. lentillifera polysaccharides will be worthy to investigate to an natural immunopotentiator.