The role of antibiotic and probiotic therapies in current and future management of inflammatory bowel disease

Abundant evidence indicates that the intestinal microflora have a role in the pathogenesis of inflammatory bowel disease (IBD). The composition of the gut microflora is altered in IBD patients with increased "pathogenic" bacteria and decreased bifidobacteria and lactobacilli. In light of t...

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Bibliographic Details
Published inCurrent gastroenterology reports Vol. 8; no. 6; pp. 486 - 498
Main Authors Ewaschuk, Julia B, Tejpar, Qassim Z, Soo, Isaac, Madsen, Karen, Fedorak, Richard N
Format Journal Article
LanguageEnglish
Published United States Springer Nature B.V 01.12.2006
Subjects
Anti-Bacterial Agents - therapeutic use
Humans
Inflammatory Bowel Diseases - drug therapy
Probiotics - therapeutic use
Remission Induction - methods
Treatment Outcome
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Summary:Abundant evidence indicates that the intestinal microflora have a role in the pathogenesis of inflammatory bowel disease (IBD). The composition of the gut microflora is altered in IBD patients with increased "pathogenic" bacteria and decreased bifidobacteria and lactobacilli. In light of this dysbiosis, various methods have been examined to alter the composition of the intestinal microflora, including the administration of antibiotics and introduction of probiotic species. This article summarizes studies evaluating the efficacy of antibiotics and probiotics in the induction and maintenance of remission of ulcerative colitis, Crohn's disease, and pouchitis.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
ISSN:1522-8037
1534-312X
DOI:10.1007/s11894-006-0039-z