Functional role of area 8A in the posterior dorsolateral frontal region of the human brain: A single case study

• Published in: The European journal of neuroscience Vol. 60; no. 10; pp. 6408 - 6419
• Main Authors: Tomaiuolo, Francesco, Mollaioli, Daniele, Foti, Cristina, Vicario, Carmelo Mario, Germanò, Antonino, Petrides, Michael
• Format: Journal Article
• Language: English
• Published: France Wiley Subscription Services, Inc 01.11.2024
• Subjects: Association Learning - physiology; Attention; Attention - physiology; Attention task; Brain; Brain architecture; Cortex (premotor); Environmental effects; Eye; Eye movements; Eye Movements - physiology; Frontal Lobe - physiology; Functional morphology; Humans; Male; Motor skill learning; Psychomotor Performance - physiology; Receptive field; Sensorimotor integration; Visual discrimination learning; Visual stimuli; superior longitudinal fasciculus; area 8A; conditional associative learning; frontal eye field; frontal lobe lesion
• ISSN: 0953-816X; 1460-9568; 1460-9568
• DOI: 10.1111/ejn.16560

Area 8A has traditionally been considered to be the frontal eye field (FEF), i.e. the area for the motor production of eye movements. However, recent research has shown that the FEF lies posteriorly in premotor area 6. Research in macaque monkeys has demonstrated that, in contrast to premotor area 6, which is involved in the production of motor actions, area 8A is implicated in the cognitive allocation of attention to stimuli based on instruction cues. The aim of the present study was to elucidate the specific cognitive role of area 8A by examining a unique patient with a lesion restricted to area 8A, i.e. sparing the premotor cortex. This right‐handed male patient underwent neuropsychological assessment and testing on two conditional associative‐learning tasks: the motor hand conditional associative‐learning task (MCALT) assessing the selection of motor actions based on instruction cues and the visual conditional associative‐learning task (VCALT) assessing the selection of visual stimuli based on instruction cues. The patient's performance on the VCALT was significantly impaired compared to control subjects, but performance on the MCALT and on an Eye Movement Control Task was preserved. The present study provides evidence that area 8A is critical for the cognitive process regulating the allocation of attention to different stimuli in the environment, but not in the production of eye movements. These findings enhance understanding of the functional organization of the posterior dorsolateral frontal region in the human brain and suggest a specialized role of area 8A in high‐level cognitive processes.