How could a pooled testing policy have performed in managing the early stages of the COVID‐19 pandemic? Results from a simulation study

• Published in: Statistics in medicine Vol. 43; no. 11; pp. 2239 - 2262
• Main Authors: Heath, Bethany, Villar, Sofía S., Robertson, David S.
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 20.05.2024
• Subjects: Computer Simulation; COVID-19; COVID-19 - diagnosis; COVID-19 - epidemiology; COVID-19 Testing - methods; COVID-19 Testing - statistics & numerical data; Data models; Epidemics; Health Policy; Humans; Models, Statistical; Pandemics; SARS-CoV-2; Sensitivity analysis; Simulation; United Kingdom - epidemiology; United Kingdom; community model; non‐compliance; false negatives; testing policy; pandemic preparedness
• ISSN: 0277-6715; 1097-0258; 1097-0258
• DOI: 10.1002/sim.10062

A coordinated testing policy is an essential tool for responding to emerging epidemics, as was seen with COVID‐19. However, it is very difficult to agree on the best policy when there are multiple conflicting objectives. A key objective is minimizing cost, which is why pooled testing (a method that involves pooling samples taken from multiple individuals and analyzing this with a single diagnostic test) has been suggested. In this article, we present results from an extensive and realistic simulation study comparing testing policies based on individually testing subjects with symptoms (a policy resembling the UK strategy at the start of the COVID‐19 pandemic), individually testing subjects at random or pools of subjects randomly combined and tested. To compare these testing methods, a dynamic model compromised of a relationship network and an extended SEIR model is used. In contrast to most existing literature, testing capacity is considered as fixed and limited rather than unbounded. This article then explores the impact of the proportion of symptomatic infections on the expected performance of testing policies. Symptomatic testing performs better than pooled testing unless a low proportion of infections are symptomatic. Additionally, we include the novel feature for testing of non‐compliance and perform a sensitivity analysis for different compliance assumptions. Our results suggest for the pooled testing scheme to be superior to testing symptomatic people individually, only a small proportion of the population () needs to not comply with the testing procedure.