Neuronal protein phosphorylation: Recent studies concerning protein I, A synapse-specific phosphoprotein

Recent studies are described concerning the physiological role and tissue distribution of Protein I, a synapse-specific phosphoprotein. This protein is present in both the central and the peripheral nervous system and appears to be enriched in synaptic vesicles. It is a major substrate for both Ca 2...

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Published inPharmacology, biochemistry and behavior Vol. 13; pp. 169 - 174
Main Authors Dolphin, Annette C., Goelz, Susan E., Greengard, Paul
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 1980
Subjects
Animals
Brain
Cyclic AMP
Cyclic AMP - metabolism
Mianserin - pharmacology
Nerve Tissue Proteins - metabolism
Nervous System - metabolism
Neurons - metabolism
Neurotransmitter Agents - pharmacology
Phosphorylation
Protein I
Protein phosphorylation
Serotonin
Serotonin - physiology
Synapses - physiology
Synapsins
Synaptic Membranes - metabolism
Cyclic AMP
Brain
Protein I
Serotonin
Protein phosphorylation
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Summary:Recent studies are described concerning the physiological role and tissue distribution of Protein I, a synapse-specific phosphoprotein. This protein is present in both the central and the peripheral nervous system and appears to be enriched in synaptic vesicles. It is a major substrate for both Ca 2− and cyclic AMP-dependent phosphorylation in the brain. In slices of the facial motor nucleus from rat brainstem, serotonin (5-HT) added to the incubation medium stimulates the phosphorylation of Protein I. This effect is potentiated by low concentrations of isobutylmethylxanthine and is prevented by the serotonin antagonist mianserin.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0091-3057
1873-5177
DOI:10.1016/S0091-3057(80)80027-X